Table 4. Association of C1orf64 expression with clinical and pathological features in breast cancer.
Feature | Histology | Grade | ER | ErbB2 | TN status | Outcome | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subtype | ductal | lobular | 1 | 2 | 3 | Neg | Pos | Neg | Pos | TN | others | good | poor |
C1orf64 log2 | 0.58 | 1.96 | 1.07 | 0.82 | 0.46 | 0.03 | 1.42 | 0.52 | 0.61 | 0.02 | 0.87 | 1.44 | 1.27 |
p value | 0.02* | <0.02* | <0.01* | >0.05 | <0.01* | >0.05 | |||||||
Fold difference | 2.6 | 1.5 | 1.3 | 2.6 | N/A | 1.8 | N/A | ||||||
Number of datasets | 15 | 18 | 18 | 17 | 16 | 8 |
C1orf64 differential analysis was carried out using the breast cancer datasets available in ONCOMINE.
P values are for the following comparisons: ductal vs. lobular; grade 1 vs. grade 3; grade 2 vs. grade 3; ER-negative (Neg) vs. ER-positive (Pos); ErbB2-neg vs. ErbB2-pos; triple negative (TN) vs. other biomarker status; good outcome (good: no recurrence or death in 5 years) vs. poor (recurrence or death in 5 years). C1orf64 expression log2 values are the median of measurements across the datasets. The number of datasets analyzed for each subtype is shown and fold difference in C1orf64 expression is presented for each significant p value. P values are calculated using Wilcoxon Signed Rank Test. *, depicts significance at < 0.05. N/A: not applicable.