Fig. 4.

Geraniin inhibits the growth of human glioma cells in vivo. a Tumor growth curves were determined for U87 xenograft tumors treated with geraniin (60 mg/kg) or vehicle every 4 days for 20 days. b Tumors were removed and weighed at 20 days after geraniin treatment. c TUNEL analysis was performed to detect apoptosis in U87 xenograft tumors after geraniin treatment. Top representative sections with TUNEL staining. Bottom quantification of the percentage of TUNEL-positive cells in tumors. Scale bar 100 μm. d Western blot analysis of STAT3 phosphorylation in U87 xenograft tumors. Bottom quantification of the Western blots. *P < 0.05 versus control