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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1998 Apr 28;95(9):5420.

Biochemistry. In the article “Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila” by Jan A. van der Knaap, Jan Willem Borst, Peter C. van der Vliet, Reiner Gentz, and H. Th. Marc Timmers, which appeared in number 22, October 28, 1997, of Proc. Natl. Acad. Sci. USA (94, 11827–11832), the following correction should be noted.

Recently, we described cloning of the cDNA encoding the TAFII170 subunit of B-TFIID transcription factor (Proc. Natl. Acad. Sci. USA, 94, 11827–11832). Comparison with the GenBank database indicated that human TAFII170 is highly related to yeast MOT1p and Drosophila melanogaster 89B Helicase. Inspection of the Drosophila FlyBase website* revealed that the 89B Helicase is encoded by the Trithorax group gene moira. By analogy, we speculated that the TAFII170 protein may serve a similar role in mammalian development. The assignment of 89B Helicase as the product of the moira gene was based on preliminary Southern blot analyses (Naomi B. Zak, personal communication). More recent experiments suggest that a locus immediately adjacent to the 89B Helicase gene corresponds to the moira gene (Madeline Crosby and Naomi B. Zak, personal communication). Work in progress should ascertain the identity of moira. Until this has been clarified, assignment of the 89B Helicase as the product of moira is premature. The website in the FlyBase* has been corrected accordingly. We apologize for any confusion created by our assumption of TAFII170 as a mammalian Trithorax group gene.

Footnotes

Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138.


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