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. Author manuscript; available in PMC: 2017 Nov 22.
Published in final edited form as: Oncogene. 2017 May 22;36(38):5421–5431. doi: 10.1038/onc.2017.143

Figure 5. Frax1036 and PD-901 combination inhibits MPNST local tumor growth.

Figure 5

Nu/nu immunodeficient mice bearing STS26T or S462TY subcutaneous xenograft tumors (~100 mm3) were allocated into four groups (n=6) and exposed to vehicle only, Frax1036, PD-901 or combination of Frax1036 and PD-901 for a period of four weeks. A. Volumetric changes of STS26T and S462TY xenograft tumors in control and experimental groups. B. IHC analysis of phospho-histone H3 (pHH3) and cleaved caspase 3 (CC3) in all groups of STS26T and S462TY tumors at study termination. Error bars represent standard error of the mean (*= p<0.05, **= p<0.01).