Skip to main content
. Author manuscript; available in PMC: 2017 Nov 22.
Published in final edited form as: Oncogene. 2017 May 22;36(38):5421–5431. doi: 10.1038/onc.2017.143

Figure 6. Frax1036 and PD-901 combination inhibits formation and growth of experimental MPNST metastasis.

Figure 6

SCID immunodeficient mice tail-vein injected with STS26T-Luc were exposed to vehicle, Frax1036, PD-901 or a combination of Frax1036 and PD-901 in the course of three weeks. The kinetics of pulmonary tumor growth and spreading was monitored by BLI. A. Quantification of BLI signals in lung area of mice in control and experimental groups (n=7). Representative BLI images are shown on day 21 after grafting. B. Representative H&E sections of the lungs of mice from each group, showing lung tumor deposits (arrowed) in control, Frax1036 or PD-901 treated groups, but not in combinatorial treatment group. C. Quantification of relative lung weights in all groups at study termination. Error bars represent standard error of the mean (*= p<0.05, **= p<0.01, ***= p<0.005).