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. 2017 Jun 28;8(38):63665–63679. doi: 10.18632/oncotarget.18885

Figure 8. A summarize of BAs dysregulation in CAC mice.

Figure 8

CAC mice complicated with BA accumulation due to BA oversynthesis in liver and blocked enterohepatic circulation. In the ileum, NRs responsible for transcriptional regulation of BA transportation are found to be down regulated in the ileum of CAC mice, down regulation of BA transporters leads to BA malabsorption, combined with accelerated glucuronidation of BA, resulting in decreased FXR ligands concentration and FXR/FGF15 signaling in the ileum, promoting CYP7A1-mediated de-novo synthesis of BAs. BA malabsorption also leads to BA accumulation in colon, especially primary BAs, due to defected transformation of primary BAs to secondary BAs in CAC mice.