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. 2017 Jul 22;8(38):63738–63749. doi: 10.18632/oncotarget.19478

Table 2. KEGG pathway analysis of differentially expressed genes associated with NPC.

Term Count % P Value Genes
Up-regulated
hsa04110: Cell cycle 20 11.8 1.94E-16 CDC6, CDK1, SKP2, TTK, CHEK1, ESPL1, PTTG1, MCM4, CCNB1, CCNE2, MAD2L1, MCM7, CCNB2, BUB1, PCNA, BUB1B, MDM2, GADD45A, CCNA2, BUB3
hsa04115: p53 signaling pathway 10 5.9 9.04E-08 BID, CCNB1, CCNE2, CDK1, CCNB2, RRM2, MDM2, CHEK1, PMAIP1, GADD45A
hsa03030: DNA replication 7 4.1 3.92E-06 RFC5, RFC3, MCM7, POLD1, POLE, PCNA, MCM4
hsa05222: Small cell lung cancer 9 5.3 7.66E-06 CCNE2, CKS1B, COL4A2, COL4A1, ITGAV, CKS2, SKP2, LAMB1, FN1
hsa04512: ECM-receptor interaction 7 4.1 6.20E-04 COL4A2, COL4A1, ITGAV, HSPG2, LAMB1, FN1, HMMR
hsa05200: Pathways in cancer 14 8.3 8.32E-04 BID, WNT5A, CKS1B, COL4A2, COL4A1, SKP2, BIRC5, MECOM, CCNE2, ITGAV, CKS2, MDM2, LAMB1, FN1
hsa04114: Oocyte meiosis 7 4.1 2.0E-03 CCNE2, CDK1, MAD2L1, BUB1, AURKA, ESPL1, PTTG1
hsa03420: Nucleotide excision repair 5 3.0 2.4E-03 RFC5, RFC3, POLD1, POLE, PCNA
hsa03430: Mismatch repair 4 2.4 2.6E-03 RFC5, RFC3, POLD1, PCNA
hsa04914: Progesterone- mediated oocyte maturation 6 3.6 4.0E-03 CCNB1, CDK1, MAD2L1, CCNB2, BUB1, CCNA2
hsa05166: HTLV-I infection 9 5.3 0.012 WNT5A, MAD2L1, POLD1, POLE, PCNA, BUB1B, CHEK1, PTTG1, BUB3
hsa04068: FoxO signaling pathway 6 3.6 0.023 CCNB1, SGK1, CCNB2, SKP2, MDM2, GADD45A
hsa00670: One carbon pool by folate 3 1.8 0.024 TYMS, SHMT2, DHFR
hsa00240: Pyrimidine metabolism 5 3.0 0.037 TYMS, UMPS, POLD1, RRM2, POLE
hsa05203: Viral carcinogenesis 7 4.1 0.038 CCNE2, CDK1, SKP2, MDM2, CHEK1, PMAIP1, CCNA2
Down-regulated
hsa05016: Huntington's disease 8 3.4 2.0E-03 DNAH9, DNALI1, DNAI1, CREBBP, DNAH3, DNAH2, DNAH7, DNAH6
hsa01100: Metabolic pathways 20 8.5 0.016 GDA, ADSSL1, GMDS, GNE, DHRS9, ADH7, COMT, CDS1, AK7, AGMAT, MAN1C1, ALDH3A1, DGKA, ALOX15, ATP6V0E2, GCK, FUT3, MGLL, FUT2, ATP6V0A4
hsa00982: Drug metabolism–cytochrome P450 4 1.7 0.026 FMO5, GSTA3, ADH7, ALDH3A1
hsa04530: Tight junction 5 2.1 0.040 PRKCA, CGN, MYH11, CLDN10, CLDN23
hsa00350: Tyrosine metabolism 3 1.3 0.042 ADH7, COMT, ALDH3A1