Colloquium Paper. In the article “A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain” by Frank Porreca, Josephine Lai, Di Bian, Sandra Wegert, Michael H. Ossipov, Richard M. Eglen, Laura Kassotakis, Sanja Novakovic, Douglas K. Rabert, Lakshmi Sangameswaran, and John C. Hunter, which appeared in number 14, July 6, 1999, of Proc. Natl. Acad. Sci. USA (96, 7640–7644), the authors request that the following correction to the legend for Fig. 6 be noted. The figure and its legend are shown below:
Figure 6.
Immunohistochemical (peroxidase-diaminobenzidine) analysis of NaN/SNS2 antibody labeling of L4 DRG cells from normal and SNL animals. (A) Naive animals show labeling of small diameter neurons with NaN/SNS2 antibody. No labeling is seen in the preabsorbed control group (B). In contrast, sham-operated (C) or SNL (E) animals that had received AS ODN to NaN/SNS2 for 48 hr (a total of four injections) demonstrated a marked loss of NaN/SNS2 immunolabeling in small cells of the L4 DRG ipsilateral to the side of surgery. Labeling for NaN/SNS2 returned in both sham-operated (D) or SNL rats (F) that were perfused 4 days after the last AS ODN to NaN/SNS2 injection. (Bar = 50 μm.)