Abstract
Gamma-band oscillations (GBO) in frontal cortex have been related to high-order cognition or perceptual processing, and hypothesized to reflect the functionality of interneuron network. Binding local dot motions into global coherent pattern elicits frontal GBO in healthy human brain, whereas the patients with abnormal GABA-mediated interneuronal network show impaired frontal GBO in response to coherent dot pattern (Skosnik et al., 2014; Neuropsychopharmacology). Here, we investigated whether the coherent random dot pattern induces frontal GBO in the mouse model as well. Frontal and visual EEGs from C57BL/6 mice were recorded during the presentation of random dot kinematogram display and EEG gamma power was analyzed. We found induced GBO in mouse frontal cortex by the visually-presented coherent dot motion, but not by the static image of random dot pattern. In addition, power of the induced GBO was degraded by optogenetic suppression of cortically-projecting PV+ neurons in basal forebrain, which have been suggested to modulate the frontal GBO (Kim et al., 2015; PNAS). As growing number of studies use mouse model for interneuron-related psychiatric disorders such as schizophrenia, our findings suggest random dot kinematogram can be a well-suited method for assessing GBO in the mouse brain.
Keywords: Gamma oscillations, Motion perception, Random dots
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Topic: [Clinical / Pre-clinical / Translational]
Sub Topic(by disorder): [Attention deficit / Dimentia / Schizophrenia / (others)]
Sub Topic(by methodology): [Neurophysiology / Computational Neuroscience / (others)]