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. 2017 Jul 24;8(37):62793–62802. doi: 10.18632/oncotarget.19513

Figure 3. PFKFB3 inhibition results in autophagy downregulation through MAPK14-dependent manner.

Figure 3

Starvation causes activation of autophagy and MAPK14 phosphorylation. Active MAPK14 upregulates SLC2A3 expression through HIF1A stabilization and increases glucose uptake. In addition, MAPK14 induces a proteasome-dependent degradation of PFKFB3, which results in an increase of PPP at the expense of glycolysis. PPP enhancements fuels NADPH production, leading to reduced ROS levels and autophagy. Abbreviations: mitogen-activated protein kinase 14(MAPK14), Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3(SLC2A3), hypoxia-inducible factor (HIF), pentose phosphate pathway (PPP), reduced form of Nicotinamide adenine dinucleotide phosphate (NADPH), reactive oxygen species (ROS).