. 2017 May 24;8(40):66784–66795. doi: 10.18632/oncotarget.18158

Table 4. Univariate Cox regression analysis result for M stage in the 7^th& 8^th editions, both for clincial M(cM)and pathological M(pM)(MST, median survival time).

7^thcM	N	Events	MST(m)	HR	P-value
M0	409,366	261,531	25.3	-	-
M1a	41,577	36,040	7.6	M1a vs M0: 2.53	< 0.001
M1b	42,886	37,649	4.6	M1b vs M1a: 1.38	< 0.001
8^th cM	N	Events	MST(m)	HR	P-value
M0	409,366	261,531	25.3	-	-
M1a	41,577	36,040	7.7	M1a vs. M0: 2.53	< 0.001
M1b	31,283	27,123	5.2	M1b vs M1a: 1.30	< 0.001
M1c	11,603	10,526	3.5	M1c vs M1b: 1.28	< 0.001
7^thpM	N	Events	MST(m)	HR	P-value
M0	1,682	1,106	41.2	-	-
M1a	7,775	6,404	6.7	M1a vs M0: 3.13	< 0.001
M1b	15,264	13,107	5.3	M1b vs M1a: 1.21	< 0.001
8^th pM	N	Events	MST(m)	HR	P-value
M0	1,682	1,106	41.2	-	-
M1a	7,775	6,404	6.7	M1a vs M0:3.13	< 0.001
M1b	10,941	9,175	6.3	M1b vs M1a: 1.10	< 0.001
M1c	4,323	3,932	3.5	M1c vs M1b: 1.49	< 0.001

Table 4. Univariate Cox regression analysis result for M stage in the 7th& 8th editions, both for clincial M(cM)and pathological M(pM)(MST, median survival time).