Figure 6. In vivo effects of liver-specific AR overexpression or Ar deficiency on mouse Akt/mTor signaling, LDH activity, and serum and hepatic lactate concentration.

(A) Hepatic protein expression of Ki67/Akt1 in four groups of DEN-treated mice as analyzed by immunohistochemistry (A). Hepatic protein expression of Akt/mTOR signalingin four groups of DEN-treated mice (B) (n = 4). Hepatic lactate levels (C) (n = 6–8), serum lactate levels (D) (n = 6–8), hepatic LDH activity (E) (n = 6–8), serum ALT levels (F) (n = 6–8) in eight groups of DEN-treated mice. Numeric data were expressed as the mean ± SEM. NS, not significant; *p < 0.05; **p < 0.01; ***p < 0.001, compared to WT/FVB or WT/B6 respectively.