Table 4. Log rank analysis of clinical factors correlated with survivals of the WHO2007 cohort.
| Clinical factors | Median PFS in months (95% CI) | No. of patients* | P value | Median OS in months (95% CI) | No. of patients* | P value |
|---|---|---|---|---|---|---|
| Age (yrs) | ||||||
| ≤40 | 41.0 (28.0-54.0) | 157 | <0.001 | N/A | 159 | <0.001 |
| >40 | 13.0 (11.5-14.5) | 248 | 27.0 (21.3-32.7) | 254 | ||
| Gender | ||||||
| Male | 19.5 (14.9-24.1) | 243 | 0.824 | 45.0 (32.9-57.1) | 248 | 0.644 |
| female | 20.0 (13.8-26.0) | 162 | 36.0 (20.3-51.7) | 165 | ||
| KPS | ||||||
| ≥70 | 21.0 (15.8-26.2) | 229 | <0.001 | N/A | 232 | 0.006 |
| <70 | 12.0 (9.0-15.0) | 55 | 24.0 (14.7-33.3) | 58 | ||
| Removal degree | ||||||
| GTR | 20.0 (12.0-22.0) | 268 | 0.034 | N/A | 272 | 0.001 |
| Non-GTR | 17.0 (13.8-26.1) | 137 | 30.5 (25.9-35.1) | 141 | ||
| Tumor size | ||||||
| ≥ 6 cm | 15.0 (10.0-20.0) | 160 | 0.041 | 32.0 (22.7-41.3) | 164 | 0.034 |
| < 6 cm | 21.0 (15.7-26.3) | 245 | N/A | 249 | ||
| Ki-67 | ||||||
| <20% | 23.0 (18.2-27.8) | 296 | <0.001 | N/A | 299 | <0.001 |
| ≥20% | 11.0 (8.6-13.4) | 77 | 22.0 (16.1-27.9) | 81 | ||
| Tumor grade | ||||||
| WHO II | 48.0 (34.9-61.1) | 155 | <0.001 | N/A | 155 | <0.001 |
| WHO III | 21.0 (13.3-28.6) | 77 | 30.0 (20.2-39.8) | 78 | ||
| WHO IV | 10.0 (8.5-11.5) | 173 | 21.5 (17.5-25.5) | 180 | ||
| 1q/19p co-polysomy | ||||||
| Yes | 65.0 (11.2-118.8) | 83 | <0.001 | N/A | 83 | <0.001 |
| No | 16.0(12.4-19.6) | 322 | 34.0 (24.2-43.8) | 330 | ||
| single polysomy | ||||||
| Yes | 12.0 (9.1-14.9) | 54 | 0.001 | 21.5 (13.9-29.1) | 55 | <0.001 |
| No | 21.0 (16.1-25.9) | 351 | 51.0 (37.1-64.9) | 358 | ||
| IDH1/2 mutation | ||||||
| Yes | 28.0 (20.5-35.5) | 120 | 0.007 | 51.5 (N/A) | 123 | 0.001 |
| No | 18.0 (13.3-22.7) | 195 | 25.0 (23.3-44.7) | 199 |
*PFS was not available in 16 cases and OS was no available in 8 cases. GTR=gross-total resection.