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. 2017 Jul 8;8(40):67990–68000. doi: 10.18632/oncotarget.19092

Figure 2. Roniciclib activates caspase-3 activity and induces apoptosis in ATC cells.

Figure 2

(A) Caspase-3 activity was detected using fluorometric assay kit in cells treated with roniciclib (25 nM) or vehicle for 24 h in 8505C, 8305C and KAT18 cells. (B) Early apoptotic cells were determined by flow cytometry to detect Annexin V-positive/PI-negative staining in cells treated with roniciclib (25 nM) or vehicle for 24 h. (C) Statistical analyses of early apoptotic cells showed roniciclib significantly induced early apoptosis in 8505C, 8305C and KAT18 cells.