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The kinetic parameters of TPGS-curcumin suspension versus TPGS-stabilized curcumin nanosuspension after oral administration of 10 mg/kg BW in male healthy Wistar rats.
| Sample | T1/2-1(h) | T1/2-2(h) | AUC (µg·h/mL) | Tmax (h) | Cmax (mg/L) | R2 |
|---|---|---|---|---|---|---|
| TPGS-Curcumin suspension | 0.019 ± 0.003 | 1.359 ± 0.201 | 0.084 ± 0.05 | 1.825 ± 0.052 | 0.016 ± 0.006 | 0.927 |
| TPGS-stabilized curcumin nanosuspension | 0.142 ± 0.041 | 2.9623 ± 0.013 | 0.562 ± 0.112 | 0.718 ± 0.210 | 0.090 ± 0.002 | 0.993 |
n = 6 rats for each group.
