Table 3. Re-analysis of published preclinical meta-analyses using SMD.

			Precision estimate
			Standard Error			1/√n
Study	n	Observed SMD[95% CI]	Egger’s p	filled	Adjusted SMD	Egger’s p	filled	Adjusted SMD
Egan et al. (2016)	1392	0.75 [0.70, 0.80]	<2.2×10−16	252	0.42 [0.37,0.47]	2.2 × 10−11	0	N/A
Groenink et al. (2015)	43	−1.99[−2.33,–1.64]	8.5 × 10−10	0	N/A	0.68	0	N/A
Kleikers et al. (2015)	20	−1.15[−1.67; −0.63]	3.5 × 10−4	6	?	2.9 × 10−3	0	N/A
Wever et al. (2012)	62	1.54 [1.16, 1.93]	7.8 × 10−6	3	?	0.62	0	N/A
Yan et al. (2015)	60	1.58 [1.19, 1.97]	6.5 × 10−6	0	N/A	0.19	0	N/A

n = number of studies; SMD = standardized mean difference; CI = confidence interval; Egger’s p=p value for Egger’s regression; adjusted SMD = SMD after trim and fill analysis; N/A = not applicable.