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. 2017 Sep 4;6(9):e376. doi: 10.1038/oncsis.2017.75

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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β-hCG induces migration, invasion and EMT. (a) Wound healing assay in HCC1937 and HCC1937/wt BRCA1 upon silencing the endogenous β-hCG expression by transfecting with β-hCG siRNA. “Csi” represents scrambled siRNA and “β-hCG si” represents β-hCG siRNA. Graph represents the distance migrated by cells in μm. (b) Invasion assay in HCC1937 and HCC1937/wt BRCA1 upon silencing the endogenous β-hCG expression. Graph represents the total number of invaded cells. (c) Immunoflourescence of Vimentin in HCC1937 control vector transfected (HCC1937 C.vec), HCC1937 β-hCG transfected (HCC1937 β), HCC1937/wt BRCA1 control vector transfected (HCC1937/wt BRCA1 C.vec) and HCC1937/wt BRCA1 β-hCG transfected (HCC1937/wt BRCA1 β) cells. DAPI was used as nuclear stain. (d) Immunoflourescence of E-cadherin and P-cadherin in HCC1937 C.vec, HCC1937 β, HCC1937/wt BRCA1 C.vec and HCC1937/wt BRCA1 β. (e) Western blot analysis of the Vimentin and E-cadherin upon overexpression of β-hCG in HCC1937 and HCC1937/wt BRCA1 and (f) upon silencing the endogenous β-hCG expression in HCC1937 and HCC1937/wt BRCA1.