TABLE 1.

Encapsulated concentrations, encapsulation efficiency (EE), and payload for 5-FU, ATP:5-FU, FUdR, FdUMP, dFdC or dFdCMP in citrate-functionalized (Cit) CPSNPs.

Formulation	Drug Concentration (M)*	EE (mol%)*	Calculated Payload (molecules/nm3 CPSNP×10−1)†
Cit-5-FU-CPSNP	4.1 (±1.8) ×10−7	0.11 (±0.04)	0.10 (±0.07)
Cit-ATP:5-FU-CPSNP	1.8 (±2.5) ×10−6	0.36 (±0.39)	0.47 (±0.54)
Cit-FUdR-CPSNP	2.8 (±1.2) ×10−8	<0.01	0.07 (±0.03)
Cit-FdUMP-CPSNP	3.0 (±1.4) ×10−4	41 (±16)	32 (±16)
Cit-dFdC-CPSNP	1.9 (±0.6) ×10−9	<0.01	0.01 (±0.01)
Cit-dFdCMP-CPSNP	2.3 (±0.4) ×10−5	22 (±6)	3.6 (±1.6)

^*Expressed as the mean ±95% CI of n=4–6 experimental replicates.

^†Particle number concentration by volume (particles/ml) is listed in Table S1 of supplementary information.