Table 2.

Top Canonical pathways in BMDMs during infection with either hypo- or hypervirulent M.tb.

Hypervirulent infected BMDMs
Pathway	p-value	Overlap
Role of BRCA1 in DNA Damage Response	4.79E − 14	44.9% 35/78
Hereditary Breast Cancer Signaling	6.50E − 14	36.5 % 46/126
Mismatch Repair in Eukaryotes	6.91E − 14	93.8 % 15/16
Cell Cycle Control of Chromosomal Replication	2.18E − 13	73.1% 19/26
GADD45 Signaling	2.93E − 10	73.7 % 14/19
Hypovirulent infected BMDMs
Pathway	p-value	Overlap
Cell Cycle Control of Chromosomal Replication	1.36E − 12	73.1 % 19/26
Role of BRCA1 in DNA Damage Response	1.59E − 10	41.0 % 32/78
Hereditary Breast Cancer Signaling	7.45E − 09	31.7 % 40/126
Mismatch Repair in Eukaryotes	1.34E − 08	75.0 % 12/16
Cell Cycle:G2M DNA Damage Checkpoint Regulation	4.75E − 07	40.8% 20/49