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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Cancer. 2017 Aug 24;123(20):4075–4076. doi: 10.1002/cncr.30921

Reply to Second Malignancies in Ewing Sarcoma Survivors

Neyssa M Marina 1, Qi Liu 2, Sarah S Donaldson 3, Charles A Sklar 4, Gregory T Armstrong 5, Kevin C Oeffinger 6, Wendy M Leisenring 7, Jill P Ginsberg 8, Tara O Henderson 9, Joseph P Neglia 10, Marilyn A Stovall 11, Yutaka Yasui 12, R Lor Randall 13, David S Geller 14, Leslie L Robison 15, Kirsten K Ness 16
PMCID: PMC5626614  NIHMSID: NIHMS895565  PMID: 28837220

We read with interest the letter submitted by Sultan in response to our publication “Longitudinal follow-up of adult survivors of Ewing Sarcoma: A report from the Childhood Cancer Survivor Study”. We have reviewed their publication1 which estimated the standardized incidence ratio (SIR) of subsequent malignant neoplasms (SMNs) for Ewing sarcoma survivors diagnosed between 1973–2005 and the letter with updates which expanded the population of Ewing sarcoma survivors to 1973–2014. Both were based on the Surveillance Epidemiology and End Results (SEER) databases.2,3 While we agree that their paper and letter are generally consistent with ours, it is important to mention that the Sultan et.al. publication1 included all patients with Ewing sarcoma regardless of age and without any requirement for survival. Our study4 had two very important requirements for inclusion; all patients were younger than 21 years of age at diagnosis and had survived at least five years. When one considers these population differences, which are critical to SMN risk, it is difficult to compare SIR for SMN.

Contributor Information

Neyssa M. Marina, School of Public Health, Department of Pediatrics, Stanford University and Lucile Packard Children’s Hospital, Palo Alto, California. University of Alberta, Edmonton, Alberta, Canada.

Qi Liu, School of Public Health, Department of Pediatrics, Stanford University and Lucile Packard Children’s Hospital, Palo Alto, California. University of Alberta, Edmonton, Alberta, Canada.

Sarah S. Donaldson, Department of Radiation Oncology, Stanford University, Stanford, California.

Charles A. Sklar, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Gregory T. Armstrong, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee.

Kevin C. Oeffinger, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Wendy M. Leisenring, Seattle Children’s Hospital, Clinical Statistics, Seattle, Washington.

Jill P. Ginsberg, Department of Pediatric Oncology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

Tara O. Henderson, Pediatric Oncology, Comprehensive Cancer Center, University of Chicago, Chicago, Illinois.

Joseph P. Neglia, Department of Pediatrics, University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota.

Marilyn A. Stovall, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Yutaka Yasui, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee.

R. Lor Randall, Department of Orthopedic Surgery, Primary Children’s Hospital and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

David S. Geller, Montefiore Medical Center--Moses Campus and Orthopedic Surgery, Children’s Hospital at Montefiore, Bronx, New York.

Leslie L. Robison, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee.

Kirsten K. Ness, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee.

References

  • 1.Sultan I, Rihani R, Hazin R, Rodriguez-Galindo C. Second malignancies in patients with Ewing Sarcoma Family of Tumors: A population-based study. Acta Oncologica. 2010;49:237–244. doi: 10.3109/02841860903253538. [DOI] [PubMed] [Google Scholar]
  • 2.Surveillance, Epidemiology and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence SEER 17 Regs Limited-Use Hurricane Katrina Impacted Louisiana Cases, Nov 2007 Sub (1973–2005 varying) Linked To County Attributes - Total U.S., 1969–2005 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2008, based on the November 2007 submission.
  • 3.Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2016 Sub (1973–2014) <Katrina/Rita Population Adjustment> - Linked To County Attributes - Total U.S., 1969–2015 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2017, based on the November 2016 submission.
  • 4.Marina NM, Liu Q, Donaldson SS, Sklar CA, et al. Longitudinal follow-up of adult survivors of Ewing Sarcoma: A report from the Childhood Cancer Survivor Study. Cancer. 2017 Feb 21; doi: 10.1002/cncr.30627. Epub ahead of print. [DOI] [PMC free article] [PubMed] [Google Scholar]

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