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. 2017 Aug 23;152(3):494–506. doi: 10.1111/imm.12786

Figure 7.

Figure 7

Lack of Ikaros negatively impacts Foxo1 gene expression. (a, b) Quantitative RT‐PCR analyses performed using cDNA from wild‐type and Ikaros null (IK −/−) purified splenic CD4+ T cells. Data are compilation of results from nine independent experiments (NS = Not significant; *P = 0·0121). (c) Purified CD4 T cells from spleens of wild‐type and Ikaros null mice were transduced with retroviruses prepared from the MSCV IRES H‐2Kk (MSCV) or MSCV IRES Ik‐1 H‐2Kk (IK‐1) constructs. Results of quantitative RT‐PCR analyses for Foxo1 expression from two independent experiments are shown. Results have been normalized to expression levels in control (MSCV) transduced cells. Error bars are representative of ± SEM.