Figure 8. Ensembles of structures populated by NH₂htau in aqueous solution differ from those by its reverse sequence.

A. EOM starting pool of conformations (gray shaded curves) and selected ensembles (filled square) for NH₂htau (a) and its reverse counterpart (b). B. contact maps (C_α–C_α distance between all pairs of residues) of four highly probable conformations, namely: a highly probable NH₂htau/reverse sequence conformation extracted from the peak at low R_G values (a-c) and high R_G value (b-d). Distances between different residues are expressed in Å (a cut-off distance at 14 Å was used). In the figure insets, a snapshot of the corresponding configuration is reported.