Figure 5. Survival curve of infected mice treated with RN7-IN10 and RN7-IN8.

Kaplan–Meier with log-rank test (Mantel-Cox) was used to perform the statistical analysis for all of the treated groups and the untreated control using. Treatment with RN7-IN8 at 20 mg/kg displayed the highest survival rate of 50% up to seven days post-infection (p < 0.001).