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. 2015 Jun 19;3(2):224–248. doi: 10.3390/toxics3020224

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Calbindin immunocytochemistry in the Purkinje cell layer. At PD11, control rats (ctr) show intense labelling in the Purkinje cell cytoplasm; strong immunoreactivity is detected in the molecular layer, in the dendrite tree branches of Purkinje cells. After cisPt treatment, atrophy of Purkinje cell dendrite is observed as well as decreased intensity in the immunoreaction. After PtAcacDMS, Purkinje cells display the same intense labelling and dendrite morphology as in controls. At PD17, compared with controls, cisPt induces an evident decrease in the labelling of dendrite branches of Purkinje cells, while no changes are visible after PtAcacDMS. Histograms show the OD values and the significance of differences is reported (** p < 0.01; *** p < 0.001). ml: Molecular layer; igl: Internal granular layer; Pl: Purkinje cell layer. Scale bar: 50 μm.