Table 1.

History of ethanol experience increased BrdU+ cells that were at proximal and intermediate distance from PECAM1 in both CIE-ED and ED; both were normalized following wheel access during abstinence. F-statistics from 2-way ANOVAs are presented (F_e, ethanol history, 3 levels; F_w, wheel access, 2 levels; F_i, interaction)

		Ethanol Naïve	ED	CIE-ED	Fe	Fw	Fi
Proximal	Wheel(-)	0.20 ± 0.08	2.3 ± 0.53 #	3.0 ± 0.69 #	8.21a	14.2b	2.87
	Wheel(+)	0.08 ± 0.08	0.73 ± 0.32*	0.78 ± 0.29*
Intermediate	Wheel(-)	0.67 ± 0.41	5.2 ± 0.46 #	5.6 ± 0.89 #	19.9a	39.1b	9.47c
	Wheel(+)	0.80 ± 0.45	1.5 ± 0.26 *	1.8 ± 0.25*
Distal	Wheel(-)	0.13 ± 0.09	1.3 ± 0.46	0.97 ± 0.76	1.12	4.91b	1.62
	Wheel(+)	0.26 ± 0.14	0.17 ± 0.09	0.07 ± 0.07

^ap<0.001, significant main effect of ethanol history,

^bp<0.05, significant main effect of wheel access,

^cp<0.001, significant interaction,

^#p<0.05, compared to ethanol naïve control;

^*p<0.05, compared to respective Wheel(-)