Figure 2. Low dose resveratrol inhibits hyperalgesic priming induced by plantar incision.

All animals received a plantar incision on the left hindpaw. Animals received 2 intraplantar injections of resveratrol (1 or 3 μg) or vehicle immediately following incision and 1-day post surgery and animals were assessed for mechanical sensitivity by von Frey hair stimulation at the indicated time points. A) Low dose resveratrol (1 or 3 μg) injection had little effect on incision-induced acute hypersensitivity (B) while just the 3 μg intraplantar injection of resveratrol immediately following incision surgery significantly attenuated development of plantar incision-induced hyperalgesic priming precipitated by PGE₂ injection on day 14 after incision. Behavioral data was analyzed by two-way ANOVA with Bonferroni post hoc test. * p < 0.05, ** p < 0.01, *** p < 0.001 (n = 6, vehicle and 1 μg resveratrol; n = 5, 3 μg resveratrol).