Table 1. Transcription factors associated with G protein signaling that are predicted to be present in the promoter regions of NME1 and NME2.

TFs	Relevant G protein subunits	No. of predicted TF binding sites*		Relation to Nm23-H1/2 expression	References
		NME1	NME2
AP-1	Gq, G12	5	2	Presence of multiple AP-1 sites on NME1 promoter	Okada et al., 1996 [12]; Chen et al., 1994 [13]; de la Rosa et al., 1996 [20]
CREB	Gs	7	4
NFAT	Gq, Gβγ	2	3
NFκB	Gi/o, Gq	1	1	CARMA3 represses NME2 via NFκB	Chang et al., 2015 [40]
SRE	G12, Gq	0	2
STAT	Gs, Gq, Gβγ	4	3	Negative feedback between STAT3 and Nm23-H1	Gong et al., 2013 [36]

* Numbers of binding sites are predicted by MatInspector.