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. 2017 Aug 1;8(41):71292–71316. doi: 10.18632/oncotarget.19772

Table 1. Direct miR-708-5p targets.

Name of Target Cancer Function Role in Cancer Reference
Rhodopsin N/A Light sensitivity N/A 31
FOXO3 ALL Pro-apoptotic signaling, LIC maintainence Pro/anti-tumorigenic 73
CD38 N/A immune checkpoint signaling Poor prognostic marker in leukemias 35
IKKβ CLL NF-kB activator pro-tumorigenic 33
Caspase-2 Bladder DNA repair & pro-apototic signaling anti-tumorigenic 94
CDKN2B CRC Cell cyle inhibitor anti-tumorigenic 98
NNAT Breast, Prostate Increased Ca2+ to promote ERK/FAK signaling pro-tumorigenic 53, 164
CD276 Breast Inhibits T-cell activation pro-tumorigenic 111
LSD1 Breast Demethylase pro-tumorigenic 117
EYA3 Ewing's Sarcoma DNA repair pro-tumorigenic 131
Rap1b Ovarian promotes integrin-mediated focal adhesion pro-tumorigenic 44
CD44 Prostate various oncogenic pathways pro-tumorigenic 160
AKT2 Prostate PI3K signaling pro-tumorigenic 160
KPNA4 Prostate shuttles transcription factors into nucleus pro-tumorigenic 165
BMI1 RCC DNA repair pro-tumorigenic 175
ZEB2 RCC promotes EMT pro-tumorigenic 175
Survivin RCC, Lung inhibitor of apoptosis pro-tumorigenic 175, 193
cFLIPL RCC Suppresses apoptotic signaling pro-tumorigenic 176
p21 Lung Suppresses apoptotic signaling pro-tumorigenic 193