Fig. 1. Bromodomains with reported inhibitors. A. Brd inhibitors such as LP99 (pale ball and stick) bind in the acetyl lysine binding pocket (green ribbon) to a common Asn residue (green ball and stick) and a network of water molecules (blue CPK) (LP99 and BRD9 from PDB ID 5IGN). B. Distribution of acetyl lysine binding residues in Brd pockets. Brds are colored by their acetyl lysine binding residue (red: Asn, blue: Tyr, green: Thr, purple: Asp). All reported Brd inhibitors (grey sections of bars) target Brds with a typical Asn residue with the exception of PHIP(2) which has a Thr. C. Brds in grey boxes have reported inhibitors. Brds in colored typeface have no reported inhibitors (colors as in B).
