Intrasession repeatability of ocular anatomical measurements obtained with a multidiagnostic device in healthy eyes

Abstract

Background

To evaluate the intrasession repeatability of anterior chamber depth (ACD), central (CCT) and peripheral corneal thickness (PCT), white-to-white diameter (WTW), and irido-corneal angle (IA) measurements obtained with a multidiagnostic device in healthy eyes.

Methods

A total of 107 eyes of 107 patients ranging in age from 23 to 65 years were examined with the VX120 system (Visionix-Luneau Technologies). Three consecutive measurements were obtained with this device to assess the intrasession repeatability of ACD, CCT, PCT at different nasal and temporal locations, WTW, and nasal and temporal IA. Data analysis included the calculation of within-subject standard deviation (S_w), intrasubject precision (1.96xS_w), coefficient of variation (CV) and intraclass correlation coefficient (ICC).

Results

The S_w and CV for ACD was 0.03 mm and 1.16%, respectively, with an ICC of 0.992. The S_w values for central and peripheral pachymetric measurements were below 9 μm, with CV of less than 1.6% and ICC of 0.976 or higher. For IA measurements, S_w values of 0.84 or lower were found, with a CV between 1 and 2%, and an ICC of more than 0.970. The S_w for WTW was 0.24 mm and the CV was 1.95%. No statistically significant correlations were found between any anatomical parameter evaluated and their S_w and CV values associated (−0.220 ≤ r ≤ 0.204, p ≥ 0.125).

Conclusions

The VX120 system is able to provide repeatable measurements of anatomical parameters in healthy eyes. Inter-observer repeatability should be evaluated in future studies.

Background

Accurate measurement of different anatomical dimensions of the anterior segment is crucial in the eye care clinical practice [1]. These accurate measurements allow the clinician to perform a precise planning of refractive and intraocular surgical procedures, to check the viability of a specific type of surgical technique, and to perform comprehensive monitoring of ocular diseases. Thus, clinical decisions based on unreliable or not consistent data are avoided. There are several studies evaluating the repeatability of anterior segment anatomical measurements provided by different types of instruments, most of them based on Scheimpflug imaging or partial coherence interferometry [2–19]. Specifically, good intrasession repeatability data have been reported with a variety of devices for anterior chamber depth (ACD), [2–19] central corneal thickness (CCT), [4, 6, 10, 13–18] peripheral corneal thickness (PCT) [21], white-to-white corneal diameter, [3, 5, 8–10, 14, 15, 20] and irido-corneal angle (IA) [6, 10, 19, 21]. All these studies confirm the good performance of currently available devices for measuring the anatomical dimensions of the anterior segment of the eye.

Recently, a new multidiagnostic platform has been developed that provides automatic measurements of corneal topography, corneal, internal and ocular aberrations, pachymetry, anterior chamber depth, irido-corneal angle, pupil diameter under different luminance conditions and intraocular pressure (IOP), which is the VX120 system (Visionix-Luneau Technologies, Chartres, France). To date, there are no scientific studies evaluating the reliability of this device. The aim of the current study was to evaluate the intrasession repeatability of anterior segment anatomical measurements obtained with the VX120 system in a sample of normal healthy eyes.

Methods

Patients

A total of 107 healthy eyes of 107 patients ranging in age from 23 to 65 years old were enrolled in this prospective study of evaluation of a technology. All subjects were selected randomly from patients attending to the Optometry Clinic of the University of Alicante, where this investigation was developed. One eye only from each subject was chosen randomly for the study using a random number sequence (dichotomic sequence, 0 and 1) in order to avoid the potential interference of the correlation that often exists between the two eyes of the same person. All patients were informed previously about the study and signed an informed consent in accordance with the tenets of the Helsinki Declaration. An approval for the performance of the study was obtained from the Ethics Committee of the University of Alicante (Spain).

The inclusion criteria were the following: eyes without active ocular pathology, age of more than 18 years, and the presence of a refractive error between +5.00 and −10.00 D. The following conditions were defined as exclusion criteria for the study: any systemic pathology at the moment of examination, previous ocular surgery, glaucoma, less than 18 complete consecutive Placido rings projected on the cornea and therefore considered for the corneal analysis, pseudophakia, corneal ectatic diseases, and any other type of pathological condition of the eye.

Examination protocol

A complete eye exam was performed in all cases that included measurement of uncorrected (UDVA) and corrected distance visual acuity (CDVA), manifest refraction, air tonometry (VX120 system, Visionix-Luneau Technologies, Chartres, France), and corneal topographic and anterior segment analysis with the VX120 system (Visionix-Luneau Technologies, Chartres, France). All measurements were performed by the same experienced examiner (ALN), taking three consecutive measurements in order to analyze the intrasession repeatability of some anatomical measurements. Specifically, the repeatability of the following parameters was evaluated: anterior chamber depth (ACD), peripheral corneal thickness at 1, 2 and 3 mm from vertex nasally (PCT_N1, PCT_N2, and PCT_N3), peripheral corneal thickness at 1, 2 and 3 mm from vertex temporally (PCT_T1, PCT_T2, and PCT_T3), central corneal thickness (CCT) (Fig. 1), nasal and temporal irido-corneal angles (IA_N and IA_T), and horizontal white-to-white corneal diameter (WTW).

Fig. 1.

Horizontal scan obtained with the Scheimpflug camera of the VX120 system in which peripheral pachymetric measurements are done

The VX120 system

The VX120 system is a multidiagnostic platform that combines several technologies in order to provide an integral exam of the anterior segment of the eye. Specifically, the system combines a Scheimpflug imaging-based system, a Placido disk corneal topographer, a Hartmann-Shack aberrometer, and an air tonometer. The information used to provide all corneal topographic information is provided by a Placido disk system that projects 24 rings on the corneal surface, measuring more than 100,000 points. Refractive and ocular aberrometric data are obtained with a Hartmann-Shack system that measures 1500 points in 0.2 s in an area ranging from 2.0 to 7.0 mm of diameter. The Scheimpflug imaging-based system uses monochromatic blue light of 455 nm to obtain pachymetric measurements with a resolution of ± 1 μm, and iridocorneal angle measurements with a resolution of ± 1°. With the data obtained with all these technologies, the system also provides tangential and axial curvature data of the anterior corneal surface, internal wavefront aberrations, visual quality simulations, central and peripheral corneal pachymetry data, and IOP measurements.

Statistical analysis

The statistical analysis was performed using the software SPSS version 15.0 for Windows (SPSS, Chicago, Illinois, USA). Normality of all data distributions was confirmed by means of the Kolmogorov-Smirnov test. Then, parametric statistics was applied. Intrasession repeatability for anatomical parameters was assessed according to the following variables: the within-subject standard deviation (S_w) of the 3 consecutive measurements, intrasubject precision (1.96 x S_w), and the intraclass correlation coefficient (ICC). The within-subject standard deviation (S_w) is a simple way of estimating the size of the measurement error. The intraobserver precision was defined as (±1.96 x S_w) and this parameter indicates how large is the range of error of the repeated measurements for 95% of observations. Finally, the ICC is an ANOVA-based type of correlation that measures the relative homogeneity within groups (between the repeated measurements) in ratio to the total variation. The ICC will approach 1.0 when there is no variance within repeated measurements, indicating total variation in measurements is due solely to variability in the parameter being measured. Furthermore, Pearson correlation coefficients were used to assess the correlation between different parameters evaluated. All statistical tests were 2-tailed, and p-values less than 0.05 were considered statistically significant.

Results

Table 1 summarizes the main characteristics of the sample evaluated. The sample was comprised of 49 males (45.8%) and 58 females (54.2%), with a mean age of 47.8 years old. Table 2 summarizes the outcomes of the intrasession repeatability analysis for all anatomical parameters evaluated. The S_w and CV for ACD was 0.03 mm and 1.16%, respectively, with an ICC 0.992. The S_w values for central and peripheral pachymetric measurements were below 9 μm, with CV of less than 1.6% and ICC of 0.976 or higher. For IA measurements, S_w values of 0.84 or lower were found, with a CV between 1 and 2%, and ICC of more than 0.970. The S_w for WTW was 0.24 mm and the CV was 1.95%.

Table 1.

Main characteristics of the sample evaluated

	Mean (SD)	Median	Range
Age (years)	47.8 (8.3)	47.0	23.0 to 65.0
Mean central corneal radius (mm)	7.92 (0.30)	7.86	7.26 to 8.84
Mean central corneal astigmatism (D)	0.82 (0.59)	0.75	0.00 to 3.75
Manifest sphere (D)	−0.43 (2.02)	0.00	−7.00 to 6.00
Manifest cylinder (D)	−0.40 (0.75)	0.00	−4.00 to 0.00
Manifest spherical equivalent (D)	−0.63 (2.03)	0.00	−7.33 to 5.50
Corneal eccentricity	0.34 (0.31)	0.43	−1.16 to 0.83

Abbreviations: SD standard deviation, D diopter

Table 2.

Summary of the intrasession repeatability outcomes for the anatomical measurements evaluated with the VX120 system

	Overall mean (SD) Overall median (Range)	Sw	Pr	CV (%)	ICC (Range 95% CI)
ACD (mm)	2.86 (0.29) 2.83 (2.10 to 3.77)	0.03	0.06	1.16	0.992 (0.989 to 0.994)
PCTN3 (μm)	592.04 (39.87) 601.00 (533.67 to 699.00)	8.98	17.59	1.52	0.976 (0.957 to 0.987)
PCTN2 (μm)	567.77 (37.83) 575.67 (506.33 to 675.33)	7.05	13.81	1.25	0.984 (0.971 to 0.991)
PCTN1 (μm)	574.89 (45.35) 549.67 (508.33 to 699.00)	7.70	15.09	1.34	0.984 (0.972 to 0.992)
CCT (μm)	545.88 (34.70) 544.67 (428.00 to 657.67)	6.41	12.56	1.17	0.983 (0.977 to 0.988)
PCTT1 (μm)	553.27 (37.44) 545.67 (492.00 to 664.33)	5.91	11.59	1.08	0.987 (0.977 to 0.993)
PCTT2 (μm)	568.70 (37.58) 573.33 (510.67 to 681.33)	6.06	11.87	1.07	0.987 (0.977 to 0.993)
PCTT3 (μm)	593.76 (38.58) 598.67 (529.00 to 708.00)	8.33	16.33	1.41	0.979 (0.963 to 0.989)
IAN (°)	37.17 (4.35) 37.00 (28.33 to 46.00)	0.84	1.65	2.23	0.970 (0.946 to 0.984)
IAT (°)	39.63 (4.59) 39.67 (30.67 to 50.33)	0.52	1.02	1.32	0.994 (0.988 to 0.997)
WTW (mm)	12.21 (0.57) 12.17 (10.99 to 13.94)	0.24	0.46	1.95	0.873 (0.823 to 0.911)

Abbreviations: SD standard deviation, CV coefficient of variation, S _w within-subject standard deviation, Pr intrasubject precision: 1.96 x S_w, ICC intraclass correlation coefficient, ACD anterior chamber depth, PCT _N1 , PCT _N2 , and PCT _N3 peripheral corneal thickness at 1, 2 and 3 mm from vertex nasally, PCT _T1 , PCT _T2 , and PCT _T3 peripheral corneal thickness at 1, 2 and 3 mm from vertex temporally, CCT central corneal thickness, IA _N and IA _T nasal and temporal irido-corneal angles and WTW horizontal white-to-white corneal diameter

Table 3 displays the coefficients of correlation of the magnitude of different anatomical parameters and the S_w and CV values associated to each parameter. As shown, no statistically significant correlations were found (−0.220 ≤ r ≤ 0.204, p ≥ 0.125). Likewise, no significant correlations were found between mean keratometry, corneal eccentricity, corneal astigmatism or spherical equivalent and the S_w values obtained for each anatomical parameter evaluated (−0.253 ≤ r ≤ 0.275, p ≥ 0.125).

Table 3.

Summary of correlations between the different anatomical parameters and their within-subject standard deviation (S_w,) and coefficient of variation (CV) associated

	Sw		CV
	Pearson correlation coefficient	p-value	Pearson correlation coefficient	p-value
ACD (mm)	0.033	0.734	−0.058	0.550
PCTN3 (μm)	0.024	0.893	−0.082	0.652
PCTN2 (μm)	−0.125	0.487	−0.220	0.218
PCTN1 (μm)	0.101	0.577	0.000	0.999
CCT (μm)	0.149	0.127	0.056	0.565
PCTT1 (μm)	−0.069	0.704	−0.158	0.381
PCTT2 (μm)	−0.059	0.746	−0.142	0.431
PCTT3 (μm)	0.000	0.997	−0.100	0.580
IAN (°)	0.204	0.254	0.122	0.498
IAT (°)	0.039	0.827	−0.102	0.572
WTW (mm)	−0.109	0.282	−0.154	0.125

Abbreviations: SD standard deviation, CV coefficient of variation, S _w within-subject standard deviation, Pr intrasubject precision: 1.96 x S_w, ICC intraclass correlation coefficient, ACD anterior chamber depth, PCT _N1 , PCT _N2 , and PCT _N3 peripheral corneal thickness at 1, 2 and 3 mm from vertex nasally, PCT _T1 , PCT _T2 , and PCT _T3 peripheral corneal thickness at 1, 2 and 3 mm from vertex temporally, CCT central corneal thickness, IA _N and IA _T nasal and temporal irido-corneal angles, and WTW horizontal white-to-white corneal diameter

Discussion

The concept of integrating several clinical tests in one device in order to simplify the activity in clinical setting has been investigated extensively in the last years. Some multidiagnostic platforms combining different technologies have been developed and commercially released [1, 21–23]. One of the potential concerns about these systems if they are able to provide consistent and reliable measurements that can be considered as interchangeable with those measurements provided by gold-standard or widely tested devices. The current study was aimed at confirming if one experienced operator was able to obtain repeatable measurements of different anatomical parameters of the anterior segment with the multidiagnostic platform VX120. If this intrasession repeatability is confirmed, future studies will be conducted to analyze the inter-observer repeatability and the interchangeability of VX120 measurements with those obtained by other different currently available topography systems or tomographers.

In our study, the intrasession repeatability of ACD measurements was excellent, with S_w of 0.03 mm, CV of 1.16% and ICC of 0.992. This confirms that the multidiagnostic device evaluated is able to provide repeatable consecutive measurements of the depth of the anterior chamber of the healthy eye. Our intrasession repeatability outcomes for ACD are consistent with those reported with other commercially available devices, including Scheimpflug-based topography systems, [3, 5, 6, 10–14, 16–19] biometers, [2–4, 8, 9, 15, 17] and optical coherence tomographers [3, 11] (Table 4). Kurian et al. [2] obtained in 100 eyes evaluated with the IOL-Master (Carl Zeiss Meditec) and Lenstar 900 (Haag-Streit) optical biometry systems, S_w values for ACD of 0.04 and 0.06 mm, and CV of 1.22 and 1.99%, respectively. Kunert and coauthors [4] found a S_w value for ACD of 0.0098 mm with the optical biometry system IOL Master 700 (Carl Zeiss Meditec). Other authors have also reported S_w values below 0.06 mm for the same and other optical biometers [8, 9, 15, 17]. Likewise, several studies have evaluated the consistency of ACD measurements using Scheimpflug imaging-based topography systems, such as the Sirius (CSO), Galilei (Ziemer) and Pentacam (Oculus) systems. Shin et al. [5] reported an ICC > 0.980 for ACD measurements obtained with the Galilei G6 system in a sample of 140 eyes with cataract, and Savini et al. [19] obtained CV < 3.5% and ICC > 0.94 in 45 healthy eyes using the same system. With the Sirius system from CSO, Prakash et al. [6] obtained a mean value of 0.06 mm for 1.96xS_w corresponding to ACD measurements in a sample of 100 healthy subjects. Likewise, Masoud et al. [10] obtained a CV < 2% in 100 healthy eyes of 50 patients, Nasser et al. [16] a CV of 0.56% in 45 healthy eyes, and Montalbán et al. [18] S_w, CV and ICC of 0.02 mm, 0.54% and 0.999 in 117 healthy eyes, respectively. Hernández-Camarena and coauthors [12] performed a comparative study of the repeatability of ACD measurements obtained with the Galilei G2 (Ziemer), Pentacam HR (Oculus) and Sirius (CSO) systems in 84 healthy eyes and found CV values below 1% in all cases. Shetty and coauthors [13] performed a similar comparison but in 55 keratoconus eyes and obtained S_w values of 0.03, 0.05 and 0.03 mm with the Pentacam, Galilei and Sirius systems, respectively. Therefore, the VX120 platform that uses Scheimpflug imaging for measuring ACD provides repeatable measurements of this anatomical parameter, with levels of reliability that are consistent with those found for other systems also based on Scheimpflug imaging or optical biometry (Table 4).

Table 4.

Summary of the results of previous studies evaluating the consistency of anterior chamber depth (ACD), peripheral corneal thickness (PCT), central corneal thickness (CCT), iridocorneal angle (IA), and white-to-white corneal diameter (WTW)

Authors	Year	Number of eyes	Type of eyes	System	Parameter	1.96 Sw	Sw	ICC	CoV
Kurian et al. [2]	2016	100	Healthy	IOL Master 700 Lenstar 900	ACD	–	0.04 mm 0.06 mm	–	1.22% 1.99%
Shajari et al. [3]	2016	40	Healthy	Pentacam HR IOL Master 500 Lenstar 900 Visante OCT Pentacam HR IOL Master 500 Lenstar 900 Visante OCT	WTW ACD	0.5 0.5 0.5 0.6 0.3 0.3 0.3 0.3	–	–	–
Shin et al. [5]	2016	140	Cataract	Galilei G6	WTW ACD	–	–	> 0.980	–
Kunert et al. [4]	2016	120	Cataract	IOL Master 700	CCT ACD	–	19.5 μm 9.8 μm	–	–
Prakash et al. [6]	2016	100	Healthy	Sirius	CCT ACD IA	5 μm 0.06 mm < 2°	–	–	–
Huang et al. [8]	2015	52 46	Healthy Cataract	Aladdin	WTW ACD	–	0.80 mm	> 0.94 0.795	< 0.89%
Srivannaboon et al. [9]	2015	100	Cataract	IOL Master 500/700	WTW ACD	–	–	0.93 to 1.00	–
Masoud et al. [10]	2015	100	Healthy	Sirius	IA ACD	–	–	–	<2%
Wang et al. [11]	2015	71	Healthy	Galilei G2 Visante OCT Sirius Pentacam	ACD	–	0.04 to 0.07 mm	–	–
Shetty et al. [13]	2014	55	Keratoconus	Pentacam Galilei Sirius	ACD	–	0.03 mm 0.05 mm 0.03 mm	–	1.1% 1.3% 1.0%
Hernández-Camarena et al. [12]	2014	84	Healthy	Galilei G2 Pentacam HR Sirius	CCT ACD	–	–	–	< 1%
Zhao et al. [15]	2013	56	Healthy	Lenstar 900	WTW ACD CCT	–	0.274 mm 0.052 mm 14.24 μm	–	–
Montalban et al. [14]	2013	61	Keratoconus	Sirius	WTW CCT ACD	--- ---	0.07 mm 2.30 μm 0.02 mm	0.989 0.998 0.998	0.56% 0.51% 0.64%
Chen et al. [17]	2012	40	Healthy	Sirius Lenstar 900 Sirius Lenstar 900 Sirius Lenstar 900	WTW ACD CCT	–	0.04 mm 0.05 mm 0.02 mm 0.02 mm 3.10 μm 3.32 μm	–	–
Montalban et al. [18]	2012	117	Healthy	Sirius	WTW ACD CCT	–	0.06 mm 0.02 mm 2.80 μm	0.974 0.999 0.997	0.48% 0.54% 0.52%
Nasser et al. [16]	2012	45	Healthy	Sirius	ACD	–	–	–	0.56%
Savini et al. [19]	2011	45	Healthy	Galilei	CCT IA (4 quadrants) WTW	–	–	> 0.94	< 3.5%

Abbreviations: SD standard deviation, S _w within-subject standard deviation, ICC intraclass correlation coefficient, CoV coefficient of variation, D diopter

The intrasession repeatability of central and peripheral pachymetric readings obtained with the VX120 system in our sample was also excellent, with S_w values below 9 μm, CV below 1.6% and ICC of more than 0.97. Specifically, S_w for central corneal thickness was 6.41 μm in our sample, a value which is consistent with those reported using the Sirius system in healthy (Prakash et al. [6] S_w: 5 μm; Montalbán et al. [18] S_w: 2.80 μm; Chen et al. [17] S_w: 3.10 μm) and keratoconus eyes (Montalbán et al. [14] S_w: 2.30 μm). However, VX120 pachymetric repeatability outcomes were better than those reported for optical biometry systems (Zhao et al. [15] S_w: 14.24 μm, healthy eyes; Kunert et al. [4] S_w: 19.5 μm) (Table 4). Concerning peripheral pachymetry, the readings obtained with the VX120 system were very repeatable, with S_w values ranging from 5.91 to 8.98 μm. Milla and coauthors [20] evaluated the intrasession consistency of peripheral pachymetry obtained with the Scheimpflug imaging-based topography system Sirius from CSO and obtained S_w values ranging from 3.1 to 5.8 μm. These values are consistent with those found in the current study. Likewise, other authors have reported similar S_w or even worse than those obtained in the current series for minimal corneal thickness (Shetty et al. [13] S_w 9.33 μm Pentacam, S_w 11.64 μm Galilei, S_w 8.88 μm Sirius, Montalbán et al. [14] S_w 3.18 μm) (Table 4).

Besides ACD and pachymetry, the intrasession repeatability of WTW and iridocorneal angle measurements was also evaluated. In our series, excellent intrasession repeatability was found for WTW, with values of 0.24 mm, 1.95% and 0.873 for S_w, CV and ICC, respectively. Shajari and coauthors [3] reported in a sample of 40 healthy subjects in which WTW was measured with the Pentacam HR, IOL-Master 500, Lenstar 900 and Visante systems, a value of approximately 0.5 μm for 1.96xS_w. Likewise, excellent intrasession repeatability for WTW has been also reported by other authors using a variety of devices: Galilei (Shin et al. [5] ICC > 0.980 for cataract eyes; Savini et al. [19] ICC > 0.94 for healthy eyes), Lenstar 900 (Zhao et al. [15] Sw: 0.274 μm for healthy eyes), Aladdin biometer (Huang et al. [8] ICC > 0.94 for healthy eyes, ICC: 0.795 for cataract eyes), Sirius (Montalbán et al. [14] S_w: 0.07 mm for keratoconus eyes, Montalbán et al. [18] S_w: 0.06 mm for healthy eyes), and IOL-Master system (Srivannaboon et al. [9] ICC > 0.93 for cataract eyes). Concerning iridocorneal angle, an excellent intrasession repeatability was also obtained for nasal and temporal measurements over a horizontal scan, with Sw < 0.9°, CV < 2.3% and ICC > 0.97. This level of repeatability is consistent with that reported for other Scheimpflug imaging-based topography systems [6, 10, 19]. Prakash et al. [6] reported values of 1.96xS_w < 2° in iridocorneal angle measurements obtained with the Sirius system from CSO in a sample of 100 healthy subjects. Masoud et al. [10] found CV values below 2% for anterior chamber angle measurements obtained with the same topography system in another sample of 100 healthy eyes. Likewise, Savini et al. [19] found CV values below 3.5% and ICC values of more than 0.94 for iridocorneal angle measurements in four quadrants obtained using the Galilei system in 45 healthy eyes. Therefore, the multidiagnostic platform VX120 is also able to provide repeatable measurements of WTW and iridocorneal angle, with levels of intrasession repeatability comparable to those reported for other commercially available systems (Table 4).

Finally, the level of correlation between the magnitude of all anatomical variables evaluated and their S_w and CV values associated. Thus, we investigated if the level of repeatability of each anatomical parameter was dependent on its magnitude. This analysis revealed that this dependency was not present for any anatomical variable evaluated. Therefore, the VX120 system provides anatomical measurements of the anterior segment, with minimal repeatability errors that do not seem to increase in cases with extreme values within the normal range. More studies are needed to corroborate this finding in eyes with abnormal or pathological anterior segment, such as microcorneas and ectatic corneas.

The results of this study have only demonstrated that the VX120 system is able to provide repeatable measurements, which is crucial for being used as a diagnostic tool in clinical practice. However, future studies are necessary to evaluate the inter-observer repeatability and the interchangeability of the measurements provided by the VX120 platform with those obtained with other commercially available systems. In any case, good inter-observer repeatability is expected to be found considering that measurements are taken automatically by the VX120 system, with minimal intervention from the observer. Indeed, the observer does not have to focus or center because this is done automatically by the system.

Conclusion

The multidiagnostic system VX120 seems to be able to provide consistent repeated measurements of ACD, central and peripheral pachymetry, WTW and iridocorneal angle in healthy eyes. The level of repeatability of the measurement of these anatomical parameters with the VX120 system is not dependent on the magnitude of such parameters, with the same precision ability for short and long eyes, small and large corneas, and eyes with deep and shallow anterior chamber within the normal range. Future studies should be conducted to confirm if this level of intrasession repeatability for the anatomical parameters evaluated is also observed in pathological eyes or after specific types of eye surgery. Furthermore, although measurements are done automatically by the device with minimal intervention of the operator, future inter-observer repeatability studies should be also performed.

Abbreviations

ACD

Anterior chamber depth

CCT

Central corneal thickness

CDVA

Corrected distance visual acuity

CV

Coefficient of variation

IA

Irido-corneal angle

ICC

Intraclass correlation coefficient

IOP

Intraocular pressure

PCT

Peripheral corneal thickness

PCT_N1, PCT_N2, and PCT_N3

Peripheral corneal thickness at 1, 2 and 3 mm from vertex nasally

PCT_T1, PCT_T2, and PCT_T3

Peripheral corneal thickness at 1, 2 and 3 mm from vertex temporally

UDVA

Uncorrected distance visual acuity

WTW

White-to-white diameter

Authors’ contributions

Conception and design of the study: DPP, ALN, VJC. Acquisition of data: IC, ALN; DDF. Analysis and interpretation of data: DPP, IC, DDF, MTC. Drafting of the manuscript: DPP, IC. Critically revision of the manuscript: IC; ALN, DDF, MTC, VJC. All authors read and approved the final version to be published.

Ethics approval and consent to participate

An approval for the performance of the study was obtained from the Ethics Committee of the University of Alicante (Spain). All patients were informed previously about the study and signed an informed consent in accordance with the tenets of the Helsinki Declaration.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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