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. 2017 May 22;8(43):73947–73963. doi: 10.18632/oncotarget.18166

Figure 2. HSF1 and AKT activity are predictors of metastasis-free survival of breast cancer.

Figure 2

(A–D) Using publicly-available datasets, Kaplan–Meier curves were drawn by stratifying breast cancer patients (n = 664) based on high or low expression of HSF1 along with high or low expression of HSF1 target genes Slug (A), Hsp70 (B), or Hsp90 (C) to indicate patients with high HSF1 activity and patients were also stratified by high or low AKT activity (D). Log rank test was used to determine significant differences in metastasis-free survival. (E–H) Gene set enrichment analysis was performed using a previously published signature for solid tumor metastasis. Patients were stratified as they were in (A–D), respectively.