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. 2017 Aug 22;8(43):74320–74330. doi: 10.18632/oncotarget.20382

Figure 2. Effects of melatonin and melatonin with MT2 receptor antaginist on spatial working memory in mice post-BCAS at day-28.

Figure 2

Spontaneous alternation. Group 1 = sham control, Group 2 chronic cerebral hypoperfusion(CHP) mice, Group 3: melatonin treatment in CHP mice, Group 4: addition MT2 receptor antagonist with melatonin in CHP mice. Values are mean SEM (n =10 in each group). Spontaneous alternation ratio was decreased in group 2 than group 1. The treated melatonin increased the Spontaneous alternation ratios in group 3 than group 2. However, the addition MT2 receptor antagonist with melatonin abolished the protective effect of melatonin in group 4. The p value < 0.05 indicates significance between two groups. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Number of arm entries. Group 1 = sham control, Group 2 chronic cerebral hypoperfusion(CHP) mice, Group 3 : melatonin treatment in CHP mice, Group 4 addition MT2 receptor antagonist with melatonin in CHP mice. Values are mean SEM (n =10 in each group). There was no significant difference between four groups. All statistical analyses using one-way ANOVA.