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. 2017 Aug 24;8(43):75076–75086. doi: 10.18632/oncotarget.20507

Figure 2. Kaplan-Meier analysis of overall survival.

Figure 2

(A) In a cohort comprised of 238 renal cell carcinoma (RCC) patients with clear cell histology a significant association between CDHR5 expression and overall survival after surgery was observed. CDHR5 expression was dichotomized into CDHR5-negative (n = 54) vs. CDHR5-positive (n = 184), based on the complete absence or presence of any immunohistochemical protein expression. (B) CDHR5 expression was dichotomized into luminal CDHR5 expression (n = 81) vs. diffuse or no CDHR5 expression (n = 157). In a cohort comprised of 238 clear-cell RCC cases, patients with luminal CDHR5 expression showed a significant longer overall survival after surgery compared to those with no or diffuse CDHR5 expression. (C) In 489 RCC patient samples from the TCGA cohort the prognostic value of CDHR5 expression could be confirmed (log rank p = 0.00017). CDHR5 expression values (RNASeq) were dichotomized based on the best cut-off.