Table 3. Univariate and multivariate Cox proportional hazard analyses on overall survival of clear-cell renal cell carcinoma patients from the TCGA cohort (n=489).
| Clinicopathological parameter / biomarker# | Univariate Cox | Multivariate Cox | ||
|---|---|---|---|---|
| Hazard ratio [95% CI] | p-Value | Hazard ratio [95% CI] | p-Value | |
| Tumor stage | ||||
| pT1 | 1.00 | - | 1.00 | - |
| pT2 | 1.44 [0.82-2.52] | 0.202 | 1.28 [0.72-2.26] | 0.401 |
| pT3a | 3.61 [2.45-5.33] | 9.68e-11 | 2.41 [1.58-3.69] | 4.68e-05 |
| pT3b | 3.46 [2.10-5.70] | 1.14e-06 | 2.57 [1.53-4.31] | 0.0004 |
| pT3c | 8.22 [1.98-34.13] | 0.004 | 4.55 [1.07-19.37] | 0.040 |
| pT4 | 12.55 [6.29-25.07] | 7.55e-13 | 4.64 [1.83-11.78] | 0.001 |
| ISUP grade | ||||
| Grade 2 | 1.00 | - | 1.00 | - |
| Grade 3 | 1.88 [1.26-2.81] | 0.002 | 1.48 [0.98-2.24] | 0.060 |
| Grade 4 | 5.67 [3.72-8.66] | 8.88e-16 | 2.83 [1.73-4.62] | 3.33e-05 |
| Nodal status (pN1 vs. pN0/x) | 3.75 [1.97-7.13] | 5.72e-05 | 1.12 [0.49-2.78] | 0.729 |
| CDHR5 mRNA Expression (high vs low*) | 0.55 [0.40-0.75] | 0.0002 | 0.65 [0.47-0.90] | 0.0097 |
# Surgical margin status was not available. * “high” means > cut-off, “low” means < cut-off.