Table 1.
Characteristics of Study Population by Fibrosis Stage
| Variables | Stage 0 N = 54 |
Stage 1 N = 24 |
Stage 2 N = 6 |
Stage 3 N = 5 |
Stage 4 N = 1 |
|---|---|---|---|---|---|
| Age, mean (SD), y | 13.3 (2.5) | 12.7 (2.4) | 14.8 (2.4) | 12.2 (0.6) | 12.5 (--) |
| Sex, N (%) | |||||
| Boys | 37 (68.5) | 18 (75) | 6 (100) | 5 (100) | 0 (0) |
| Girls | 17 (31.5) | 6 (25) | 0 (0) | 0 (0) | 1 (100) |
| Weight, mean (SD), Kg | 79.2 (21.3) | 80.3 (29.5) | 98.8 (24.8) | 80.5 (14.3) | 47.2 (--) |
| Height, mean (SD), cm | 161 (12) | 159 (13) | 168 (15) | 160 (6) | 138 (--) |
| BMI (Kg/m2), mean (SD) | 30.2 (5.6) | 31.0 (7.6) | 34.8 (5.6) | 31.1 (3.5) | 25.0 (--) |
| BMI Z score | 2.09 (0.37) | 2.15 (0.56) | 2.37 (0.42) | 2.26 (0.31) | 1.55 (--) |
| ALT, median (range), U/L | 50 (18–212) | 80 (17–290) | 131 (63–811) | 206 (69–522) | 302 (--) |
| AST, median (range), U/L | 38 (16–150) | 43 (16–155) | 83 (38–364) | 131 (51–330) | 226 (--) |
| GGT, median (range), U/L | 29 (11–177) | 35 (14–109) | 50 (28–232) | 67 (22–144) | 407 (--) |
| Platelet count, median (range), × 109/L | 278 (147–430) | 288 (149–412) | 294 (247–361) | 344 (218–354) | 69 (--) |
| Time between biopsy and MRI, mean (SD), days | 76 (32) | 84 (35) | 62 (21) | 90 (73) | 115 (--) |
| 2D MRE hepatic stiffness, median, kPa | |||||
| Reading Center 1 | 2.20 | 2.51 | 3.13 | 3.05 | 9.67 |
| Reading Center 2 | 2.23 | 2.42 | 3.43 | 2.80 | 10.57 |
| Automated Reading | 2.28 | 2.51 | 2.87 | 2.90 | 9.66 |