Table 1.

Factors Influencing the Initial and Trajectory of 25-Item National Eye Institute Visual Functioning Questionnaire Composite Scores during the First 3 Years of Follow-up for 127 Individuals Assigned to Undergo Implant Therapy in the Multicenter Steroid Treatment Trial and Follow-up Study

Characteristic	No. (%) at Randomization	25-Item National Eye Institute Visual Functioning Questionnaire Score at Randomization: Estimated Mean Difference at Randomization in Points (95% Confidence Interval)*	P Value
Visual acuity worse than 20/40	43 (34)	−14.95 (−21.83 to −8.07)	<0.001
Visual field impairment
Moderate (−3 to −6 dB)	38 (30)	−5.24 (−10.78 to 0.29)	0.063
Severe (<−6 dB)	50 (39)	−17.39 (−24.92 to −9.85)	<0.001
Male	37 (29)	7.30 (1.93–12.68)	0.008
Black	35 (28)	−1.63 (−8.34 to 5.08)	0.63
For each 10 yrs older than 45 yrs at randomization	127 (100)	−2.12 (−3.61 to −0.64)	0.005
Posterior uveitis or panuveitis	77 (61)	−3.09 (−8.57 to 2.38)	0.27
	No (%) at Follow-up Visits	Change in 25-Item National Eye Institute Visual Functioning Questionnaire Scores from Randomization to Follow-up: Estimated Mean Difference from Randomization to Follow-up in Points (95% Confidence Interval)*
Individuals with visual acuity 20/40 or better at randomization†
At 6 mos	78 (66)	10.51 (7.91–13.11)	<0.001
One yr or later	378 (67)	9.27 (6.19–12.36)	<0.001
Individuals with visual acuity worse than 20/40 at randomization†
At 6 mos	40 (34)	10.51 (7.91–13.11)	<0.001
One yr or later	189 (33)	17.18 (12.48–21.89)	<0.001

Visual acuity and visual field impairment was assessed in the better-seeing eye.

^*Adjusted for all factors simultaneously.

^†The change in 25-Item National Eye Institute Visual Functioning Questionnaire score from randomization to 1 year and beyond was significantly different for individuals with visual acuity worse than 20/40 at randomization versus those with visual acuity 20/40 or better at randomization (P = 0.001).