Fig. 1.

Orm1 is induced in humans and mics after PH. (a)–(c) Human data. (a) Postoperative serum Orm1 levels were examined in 10 patients who had undergone liver resection for HCC. (b) Correlation between changes in serum Orm1 at 24 h post-liver resection with the rates of liver resection (the resection volume counts per total liver volume counts). POD, postoperative days. (c) Representative photographs of IHC staining of Orm1 in commercially obtained liver sections of HCC and normal adjacent tissues in HCC patients. As a negative control (Ctl), human Orm1 antibody that had been incubated with a 5-fold (by weight) excess of blocking peptide. (d)–(g) Mouse data. (d) Time course of Orm1 gene expression in whole-liver tissues after PH (n = 3). (e) Orm1 transcript levels in whole-liver tissues and (f) serum protein levels at 48 h after PH (n = 4). (g) IHC staining of Orm1 in mouse liver tissues at 48 h after PH. P-value was assessed using Student's t-test or Mann-Whitney U test. *P < 0.05 indicates statistical significance. Scale bars, 100 μm.