Fig. 5.

Schematic diagram of a regulatory role of Orm1 on regenerating HPC proliferation. In this study, beginning with the transcriptome profiling of LSECs and HPCs during mouse liver regeneration, early transcriptional changes in injury response pathways in LSECs was observed, followed by activation of cell cycle control pathways in HPCs, and Orm1, predominantly expressed in HPCs, was found and characterized as a promising factor responsible for that by regulating HPC proliferation during liver regeneration.