Fig. 3.

SpaP B- and Cnm-mediated binding to DMBT1 correlates with individual caries scores. A) Correlation of binding of SpaP B to DMBT1 with individual numbers of caries DeFS lesions (binding to saliva generated virtually identical results, data not shown). B) Binding of Cnm-positive and Cnm-negative isolates to collagen, DMBT1, and saliva. Each isolate is marked by a dot and mean adhesion by a black line (Mann-Whitney U test). C) Correlation of binding of Cnm isolates (no. 1–12) to DMBT1 and collagen (r = 0.62, p = 0.031, respectively; data not shown). D) Deduced Cnm protein sequences of isolates no. 1–12. Substitutions are indicated with (|), translational stop codons with (*), and numbers of β-repeats with (o). LP = leading peptide. CWA = cell-wall anchoring motif.