Table 3. Univariate and multivariate analysis of clinico-pathologic parameters and overall survival in gastric cancer patients.

Parameter	Category	Overall survival		p
		HR	95% CI
Univariate
Tumor stage pT	pT1/pT2 vs. pT3/pT4	1.683	1.166-2.429	0.005
Nodal status, pN	pN0 vs. pN1/pN2/pN3	1.970	1.306-2.972	0.001
Metastasis status, pM	pM0 vs. pM1	1.301	0.765-2.211	0.331
Lymphatic vessel invasion, L	L0 vs. L1	1.535	1.047-2.250	0.028
Vascular invasion, V	V0 vs. V1	2.238	1.124-4.456	0.022
Residual tumor, R	R0 vs. R1/R2	1.691	1.006-2.845	0.048
Histologic grade, G	G1/G2 vs. G3/G4	1.539	1.034-2.292	0.034
UICC stage	I/II vs. III/IV	1.729	1.183-2.528	0.005
BUB1 expression	low vs. high	0.476	0.328-0.692	<0.001
Ki-67 expression	low vs. high	0.546	0.374-0.797	0.002
Laurén classification	intestinal vs. diffuse	0.665	0.451-0.981	0.040
Multivariate
Tumor stage pT	pT1/pT2 vs. pT3/pT4	1.312	0.885-1.944	0.177
Nodal status, pN	pN0 vs. pN1/pN2/pN3	1.669	1.074-2.594	0.023
UICC stage	I/II vs. III/IV	1.209	0.765-1.909	0.417
BUB1 expression	low vs. high	0.604	0.394-0.927	0.021
Ki-67 expression	low vs. high	0.699	0.464-1.053	0.086

Univariate Cox regression survival analysis showed that tumor stage, pT (p = 0.005), nodal status, pN (p = 0.001), lymphangiosis carcinomatosa (p = 0.028), hemangiosis carcinomatosa (p = 0.022), resection margin (p = 0.048), histological grade (p = 0.034), UICC stage (p = 0.005), Laurén classification (p = 0.04), Ki-67 expression (p = 0.002) and BUB1 expression (p < 0.001) are all associated with OS.

Multivariate Cox regression analysis confirmed nodal status (p = 0.023) and BUB1 expression (p = 0.021) as independent prognostic markers.