Table 2. Phenotypic expression of different markers in 4 CRC cell lines.
Sample ID | p53codon 72 | P53 Mut | WAF1% | MDM2% | BAX% | V14_3_3_s | AIP% | GADD45% | NOXA% | P53R2% |
---|---|---|---|---|---|---|---|---|---|---|
SW480 | Pro/Pro | R273H/P309S | 43.57 | 103.74 | 180.39 | 179.76 | 136.41 | 97.42 | 182.03 | 165.94 |
WiDr | Pro/Pro | R273H | 1.01 | 0.00 | 2.42 | 0.00 | 0.00 | 0.00 | 0.00 | 15.97 |
LS174T | Arg/Arg | Wt | –a | –a | –a | –a | –a | –a | –a | –a |
HT29 | Arg/Arg | R273H | 1.01 | 0.00 | 2.42 | 0.00 | 0.00 | 0.00 | 0.00 | 15.97 |
Abbreviations: Codon 72, p53 phenotype of codon 72 polymorphism; Pro/Pro, homozygous for proline phenotype at codon 72 of p53; Arg/Arg, homozygous for arginine phenotype at codon 72 of p53; p53 Mut, p53 mutational status. Wt, p53 wild type; –a, No publication on LS174T information on phenotype was reported; However WiDr and HT 29 are identical cell lines although status of codon 72 of p53 is different. Phenotypic expression of different markers for all these cell lines obtained from published source.