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. 2017 Aug 24;8(44):77424–77435. doi: 10.18632/oncotarget.20495

Figure 4. Silencing the endogenous GDF7 impaired tenogenic differentiation of hMSCs.

Figure 4

The siRNA targeting GDF6 or GDF7 was transfected into hMSCs as mentioned in Materials and Methods. siGDF7-2 and siGDF6-3 showed the best knockdown efficiency. The expression levels of Tnmd, Scx, collagen type I, Fmod and TNC were downregulated by the silencing of GDF7 (siGDF7-2). While, the silencing of GDF6 seems has no impact on tenogenic differentiation (siGDF6-3). The data are expressed as mean ± SD (n=3), *p<0.05.