TABLE 3.

New theory of endometriosis etiology

Endometriosis localization	Derivation
Ovarian cysts	Luteinization of unovulated (unruptured) follicle
Superficial ovarian endometriosis in the cortical layer	On the stigma after ovulation
Extra-genital endometriosis on the peritoneum	Persistence of primordial germ cells on the embryonal pathway
Endometriosis on the utero-sacral ligaments	Most common area of embryonal pathway migration from hindgut
Retrocervical endometriosis	The early pathway area of migration from hindgut
Adenomyosis	Endometrium derives from the intersection of gonadal ridges, containing primordial germ cells, with mesonephral ducts. In the uterine folds there are closer cell-to-cell communications.
Endometriosis in the other area	Primordial germ cells may migrate in the other somatic area from the hypoblast, through the endodermal gut to derivative organs
Endometriosis in urinary bladder	Bladder is derived from the hindgut, especially part of the allantois
Endometriosis in males	Male prostatic glands are analogues of female endometrium. The gubernaculum testis is similar to the uterine broad ligament