Figure 5.

Effects of ibrutinib, AVL‐292, and CNX‐774 on proliferation in HMC‐1 cells and KU812 cells. HMC‐1.1 cells, HMC‐1.2 cells, and KU812 cells were cultured in control medium (Co), control medium containing DMSO 1:1000 (DMSO), or with increasing concentrations of ibrutinib (0.001‐10 μmol/L) (A), AVL‐292 (0.001‐10 μmol/L) (B), CNX‐774 (0.001‐10 μmol/L) (C), dasatinib (0.000001‐10 μmol/L) (D), or P505‐15 (0.001‐10 μmol/L) (E) at 37°C for 48 hours. Thereafter, ³H‐thymidine uptake was measured. Results show the percentage of ³H‐thymidine uptake compared to control (Co) and represent the mean±SD of three independent experiments in each cell line. Asterisk (*): P<0.05 by Student's t test after Bonferroni correction