Figure 4.

Static and dynamic histomorphometric analysis of the tibia in ovary-intact and ovariectomized (OVX) rats following 34 days of treatment with endoxifen or vehicle. (A) M.Pm/B.Pm, MAR, BFR/B.Pm, and Oc.Pm/B.Pm for cancellous bone in the tibial metaphysis are indicated. (B) Periosteal and endosteal M.Pm/B.Pm, MAR, and BFR/B.Pm for cortical bone in the tibial diaphysis are indicated. (C) Representative images showing periosteal and endosteal fluorochrome labels (×10 magnification). The group means ± standard error are depicted. P values for the main comparisons (surgery and treatment) are indicated when the interaction was not significant. For parameters with a significant interaction, pairwise comparisons were made between individual groups, and statistically significant differences are indicated by solid lines.