Figure 5.

Serum levels of bone turnover markers in ovary-intact and ovariectomized (OVX) rats following 34 days of treatment with endoxifen or vehicle. Circulating levels of a bone formation marker (P1NP) and a bone resorption marker (CTX-1) were determined by enzyme-linked immunosorbent assay analysis. The group means ± standard error are depicted. Given significant interactions, pairwise comparisons were made between individual groups, and statistically significant differences are indicated by solid lines.