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Synthesis and characterization of PEG-KSLW and PLM-KSLW. The reaction between DSPE-PEG and KSLW at pH 5.5 in the presence of NaCNBH3 (A) and formation of KSLW-conjugated DSPE-PEG micelles (PLM-KSLW) (B). Characterization of PEG-KSLW (C) and PLM-KSLW (D) by performing MALDI-TOF MS (left) and DLS (right). (E) Average in vivo half-lives of KSLW, PEG5K-KSLW, and PLM-KSLW are shown. The y-axis represents the relative absorbance ratio of each construct-treated group vs. untreated group.
