Figure 5. Silencing SNAT1 inhibited tumor growth in vivo.

(A) Representative images of resected tumors. SOAS-2 cells stably expressing sh-SNAT1 or negative control (shNon) were subcutaneous injected into the capsule of the right armpit of nude mice (n = 6/group). After 18d of subcutaneous injected, the mice were anesthetized, and the tissue of Osteosarcoma were collected and tumor weights were calculated (B). Tumors from the mice were stained for MMP9 (C), VEGF (D), p-Akt (E), and p-mTOR (F).