Table 2. Univariate regression analyses of risk factors for cardiac events.

Risk factors	Patients,(%)	Cardiac events	OR	95% CI	P
Age
> 71 years	65 (48.9)	9 (13.8)	0.702	0.338-1.799	0.364
≤ 71 years	68 (51.1)	6 (8.8)
Performance status
≤ 1	108 (81.2)	11 (10.2)	1.112	0.752-1.328	0.628
> 1	25 (18.8)	4 (16.0)
WIC
≥ 1	52 (39.1)	9 (17.3)	0.382	0.127-1.147	0.086
< 1	81 (60.9)	6 (7.4)
Hypertension
Yes	36 (27.1)	5 (13.9)	1.403	0.445-4.428	0.563
No	97 (72.9)	10 (10.3)
History of cardiac diseases
Yes	5 (3.8)	1 (20.0)	0.491	0.151-2.710	0.538
No	128 (96.2)	14 (10.9)
Obesity
Yes	37 (27.8)	9 (24.3)	3.821	1.578-8.728	0.006
No	96 (72.2)	6 (6.2)
TNM stage
I-III	100 (75.2)	9 (9.0)	2.247	0.734-6.675	0.156
IV	33 (24.8)	6 (18.1)
Anthracycline exposure
Yes	71 (53.4)	12 (16.9)	0.250	0.067-0.932	0.039
No	62 (46.6)	3 (4.8)
Duration of trastuzumab
≥ 40 weeks	68 (51.1)	8 (11.8)	0.905	0.308-2.657	0.856
< 40 weeks	65 (48.9)	7 (10.8)
Previous radiotherapy
No	57 (42.9)	4 (7.0)	0.431	0.149-1.469	0.093
Yes	76 (57.1)	11 (14.8)
Hormone therapy
Yes	19 (14.3)	4 (21.1)	0.370	0.154-1.322	0.126
No	124 (93.2)	11 (8.9)
Receiving surgery
Yes	61 (45.9)	6 (9.8)	1.266	0.424-3.782	0.673
No	72 (54.1)	9 (12.5)

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; WIC, Charlson’s weighted index of comorbidities.