Figure 2. Treatment of PDAC cells with selinexor increased the expression of miR-145.

MiaPaCa-2 (A), AsPC-1 (B), L3.6pl (C), PANC-1 (D) and HPAC cells (E) were treated with 500 nM selinexor for 48 hours. MiaPaCa-2 cells were also treated with gemcitabine or paclitaxel for 48 hours. (F) (Gem: gemcitabine; Pac: paclitaxel). The total RNAs from each sample were extracted and subjected to real-time RT-PCR for detection of miR-145 expression (*: p<0.05; **: p<0.01).